Gene information
Official symbol F12
Official full name coagulation factor XII
Gene type protein-coding gene
Chromosome5q35.3
Resources
Entrez Gene 2161
HGNC HGNC:3530
Ensembl ENSG00000131187
Vega OTTHUMG00000163403
UCSC uc003mgo.5
GO terms: 50 records
GO Description Category LogP Number of genes Detail
GO:0002526 acute inflammatory response GO Biological Processes -34.5980034 29 More
GO:0002673 regulation of acute inflammatory response GO Biological Processes -15.6954767 14 More
GO:0004175 endopeptidase activity GO Molecular Functions -25.2809598 44 More
GO:0004252 serine-type endopeptidase activity GO Molecular Functions -24.0834770 30 More
GO:0005509 calcium ion binding GO Molecular Functions -14.7764642 80 More
GO:0005791 rough endoplasmic reticulum GO Cellular Components -2.39543019 5 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0007596 blood coagulation GO Biological Processes -44.7281461 45 More
GO:0007599 hemostasis GO Biological Processes -44.1075001 45 More
GO:0008233 peptidase activity GO Molecular Functions -21.0463733 46 More
GO:0008236 serine-type peptidase activity GO Molecular Functions -23.9716175 31 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0010755 regulation of plasminogen activation GO Biological Processes -10.5063145 8 More
GO:0016485 protein processing GO Biological Processes -23.0561441 30 More
GO:0016540 protein autoprocessing GO Biological Processes -4.82877039 5 More
GO:0017171 serine hydrolase activity GO Molecular Functions -24.8900503 32 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030193 regulation of blood coagulation GO Biological Processes -37.6853179 30 More
GO:0030194 positive regulation of blood coagulation GO Biological Processes -18.9359595 14 More
GO:0030195 negative regulation of blood coagulation GO Biological Processes -29.1940441 22 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031638 zymogen activation GO Biological Processes -13.0866363 13 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0035966 response to topologically incorrect protein GO Biological Processes -3.19318664 8 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0042730 fibrinolysis GO Biological Processes -16.7830831 11 More
GO:0045862 positive regulation of proteolysis GO Biological Processes -17.3242033 33 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050817 coagulation GO Biological Processes -44.4773041 45 More
GO:0050818 regulation of coagulation GO Biological Processes -40.0839917 32 More
GO:0050819 negative regulation of coagulation GO Biological Processes -31.8350192 24 More
GO:0050820 positive regulation of coagulation GO Biological Processes -18.6547980 14 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0051604 protein maturation GO Biological Processes -20.0856790 31 More
GO:0051917 regulation of fibrinolysis GO Biological Processes -20.6622986 13 More
GO:0051919 positive regulation of fibrinolysis GO Biological Processes -5.05559485 3 More
GO:0061041 regulation of wound healing GO Biological Processes -35.8633788 36 More
GO:0061045 negative regulation of wound healing GO Biological Processes -28.2986689 25 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0070613 regulation of protein processing GO Biological Processes -7.71267127 10 More
GO:0090303 positive regulation of wound healing GO Biological Processes -15.9447313 16 More
GO:1900046 regulation of hemostasis GO Biological Processes -39.0044157 31 More
GO:1900047 negative regulation of hemostasis GO Biological Processes -30.8008788 23 More
GO:1900048 positive regulation of hemostasis GO Biological Processes -18.9359595 14 More
GO:1903034 regulation of response to wounding GO Biological Processes -34.9293555 38 More
GO:1903035 negative regulation of response to wounding GO Biological Processes -27.3379640 26 More
GO:1903036 positive regulation of response to wounding GO Biological Processes -14.4451296 16 More
GO:1903317 regulation of protein maturation GO Biological Processes -7.52692728 10 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
Drug-Gene interaction
view
Related drugs: 2 records
Drug name Interaction type Source PMID View
bortezomib DTC 20875739 view
pentamidine isethionate DTC view
Related studies: 4 records
Molecular factor Omics type Application Objective MI type Reference
NM_000505.4:c.-4T>C genomics acute myocardial infarction[diagnosis] acute myocardial infarction Roldan V et al. Thromb Haemost. 2005
NM_000505.4:c.-4T>C genomics myocardial infarction[diagnosis] myocardial infarction Nishihama K et al. Int J Mol Med. 2007
coagulation factor XII proteomics acute myocardial infarction[diagnosis] acute myocardial infarction La Follette L et al. J Lab Clin Med. 1987
coagulation factor XII proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Grundt H et al. Am Heart J. 2004
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